Publications
Adipocyte P2Y14 receptors play a key role in regulating whole-body glucose and lipid homeostasis.
Jain S*, Pydi SP, Jung YH, Scortichini M, Kesner EL, Karcz TP, Cook DN, Gavrilova O, Wess J, Jacobson KA.JCI Insight. 2021 May 24;6(10):e146577. doi: 10.1172/jci.insight.146577.PMID: 34027896.
* Co-corresponding Author
Lack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasis.
Jain S, Pydi SP, Toti KS, Robaye B, Idzko M, Gavrilova O, Wess J, Jacobson KA.Proc Natl Acad Sci U S A. 2020 Dec 1;117(48):30763-30774. doi: 10.1073/pnas.2006578117. Epub 2020 Nov 16. PMID: 33199639.
Adenosine A1 receptor is dispensable for hepatocyte glucose metabolism and insulin sensitivity.
Jain S, Barella LF, Wess J, Reitman ML, Jacobson KA. Biochem Pharmacol. 2021 Oct; 192:114739. doi: 10.1016/j.bcp.2021.114739. Epub 2021 Aug 19. PMID: 34418353.
Purinergic signaling in diabetes and metabolism.
Jain S, Jacobson KA. Biochem Pharmacol. 2021 May; 187:114393. doi: 10.1016/j.bcp.2020.114393. Epub 2020 Dec 25. PMID: 33359363
Purinergic Signaling in Liver Pathophysiology.
Jain S, Jacobson KA. Front Endocrinol (Lausanne). 2021 Aug 11; 12:718429. doi: 10.3389/fendo.2021.718429. eCollection 2021.PMID: 34456873
Jain S, Jacobson KA. Curr Opin Pharmacol. 2022 Apr; 63:102190. doi: 10.1016/j.coph.2022.102190. Epub 2022 Feb 26. PMID: 35231671
G protein-coupled receptors: Role in metabolic disorders.
Barella LF, Jain S, Pydi SP. Front Endocrinol (Lausanne). 2022 Aug 4; 13:984253. doi: 10.3389/fendo.2022.984253. eCollection 2022.PMID: 35992121
Purinergic GPCR transmembrane residues involved in ligand recognition and dimerization.
Salmaso V, Jain S, Jacobson KA.Methods Cell Biol. 2021; 166:133-159. doi: 10.1016/bs.mcb.2021.06.001. Epub 2021 Jul 12. PMID: 34752329
Metabolic roles of G protein-coupled receptor signaling in obesity and type 2 diabetes.
Barella LF, Jain S, Kimura T, Pydi SP.FEBS J. 2021 Apr;288(8):2622-2644. doi: 10.1111/febs.15800. Epub 2021 Mar 22.PMID: 33682344
Historical and Current Adenosine Receptor Agonists in Preclinical and Clinical Development.
Jacobson KA, Tosh DK, Jain S, Gao ZG.Front Cell Neurosci. 2019 Mar 28; 13:124. doi: 10.3389/fncel.2019.00124. eCollection 2019.PMID: 30983976
Hepatic Gi signaling regulates whole-body glucose homeostasis.
Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J.J Clin Invest. 2018 Feb 1;128(2):746-759. doi: 10.1172/JCI94505. Epub 2018 Jan 16.PMID: 29337301
β-Arrestin-1 is required for adaptive β-cell mass expansion during obesity.
Barella LF, Rossi M, Pydi SP, Meister J, Jain S, Cui Y, Gavrilova O, Fulgenzi G, Tessarollo L, Wess J.Nat Commun. 2021 Jun 7;12(1):3385. doi: 10.1038/s41467-021-23656-1.PMID: 34099679
β-arrestin-1 suppresses myogenic reprogramming of brown fat to maintain euglycemia.
Pydi SP, Jain S, Barella LF, Zhu L, Sakamoto W, Meister J, Wang L, Lu H, Cui Y, Gavrilova O, Wess J.Sci Adv. 2020 Jun 5;6(23):eaba1733. doi: 10.1126/sciadv.aba1733. eCollection 2020 Jun.PMID: 32548266
Jung YH, Jain S, Gopinatth V, Phung NB, Gao ZG, Jacobson KA.Bioorg Med Chem Lett. 2021 Jun 1;41:128008. doi: 10.1016/j.bmcl.2021.128008. Epub 2021 Apr 6.PMID: 33831560
Oliva P, Scortichini M, Dobelmann C, Jain S, Gopinatth V, Toti KS, Phung NB, Junker A, Jacobson KA. Bioorg Med Chem Lett. 2021 Aug 1;45:128137. doi: 10.1016/j.bmcl.2021.128137. Epub 2021 May 26.PMID: 34048882
Pyrimidine Nucleotides Containing a (S)-Methanocarba Ring as P2Y6 Receptor Agonists.
Toti KS, Jain S, Ciancetta A, Balasubramanian R, Chakraborty S, Surujdin R, Shi ZD, Jacobson KA.Medchemcomm. 2017 Oct 1;8(10):1897-1908. doi: 10.1039/C7MD00397H. Epub 2017 Sep 6.PMID: 29423136
Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.
Pydi SP, Jain S, Tung W, Cui Y, Zhu L, Sakamoto W, Jain S, Abel BS, Skarulis MC, Liu J, Huynh T, Pacak K, Caron MG, Gavrilova O, Finkel T, Wess J.Nat Commun. 2019 Jul 3;10(1):2936. doi: 10.1038/s41467-019-11003-4.PMID: 31270323
Junker A, Renn C, Dobelmann C, Namasivayam V, Jain S, Losenkova K, Irjala H, Duca S, Balasubramanian R, Chakraborty S, Börgel F, Zimmermann H, Yegutkin GG, Müller CE, Jacobson KA.J Med Chem. 2019 Apr 11;62(7):3677-3695. doi: 10.1021/acs.jmedchem.9b00164. Epub 2019 Mar 21.PMID: 30895781
Design and in vivo activity of A3 adenosine receptor agonist prodrugs.
Suresh RR, Jain S, Chen Z, Tosh DK, Ma Y, Podszun MC, Rotman Y, Salvemini D, Jacobson KA.Purinergic Signal. 2020 Sep;16(3):367-377. doi: 10.1007/s11302-020-09715-0. Epub 2020 Jul 27.PMID: 32720036.
Jain S, Shrinet J, Tridibes A, Bhatnagar RK, Sunil S.Noncoding RNA. 2015 Nov 19;1(3):222-245. doi: 10.3390/ncrna1030222.PMID: 29861425
Jain S, Rana V, Tridibes A, Sunil S, Bhatnagar RK.Parasit Vectors. 2015 Mar 25; 8:179. doi: 10.1186/s13071-015-0772-y.PMID: 25888742.
Blood feeding and Plasmodium infection alters the miRNome of Anopheles stephensi.
Jain S, Rana V, Shrinet J, Sharma A, Tridibes A, Sunil S, Bhatnagar RK.PLoS One. 2014 May 27;9(5): e98402. doi: 10.1371/journal.pone.0098402. eCollection 2014.PMID: 24866389.
Shrinet J*, Jain S*, Sharma A, Singh SS, Mathur K, Rana V, Bhatnagar RK, Gupta B, Gaind R, Deb M, Sunil S.Virol J. 2012 May 25; 9:100. doi: 10.1186/1743-422X-9-100.PMID: 22632412.
* Shared First Author
Shrinet J, Jain S, Jain J, Bhatnagar RK, Sunil S.PLoS Negl Trop Dis. 2014 Jan 9;8(1): e2616. doi: 10.1371/journal.pntd.0002616. eCollection 2014.PMID: 24421911.